Our background

Our laboratory was created to explore the very latest in molecular profiling.

By examining diseases at a genetic level, we can predict how a disease might progress and how best to treat it.

About Sarah Cannon and its Research Institute

Sarah Cannon is the Cancer Institute of HCA. It offers integrated cancer services, with access to cutting-edge therapies, for hundreds of thousands of patients in the US and UK – a number unmatched by any single cancer centre.

Sarah Cannon Research Institute, the research arm of Sarah Cannon, is one of the world’s leading clinical research organisations conducting community-based clinical trials. It has led more than 250 first-in-man clinical trials since its inception in 1993, and has been a clinical trial leader in the majority of approved cancer therapies over the last 10 years. In both the US and the UK, it provides thousands of patients access to hundreds of clinical trials each year – trials that could help or cure them. Sarah Cannon has been a clinical trial leader in the majority of cancer therapies over the last 10 years.

Our history

In 2013, HCA UK partnered with UCL’s Advanced Diagnostics lab – known as UCLAD – to explore the latest developments in molecular pathology. This partnership created molecular pathology services within UCLAD, offering a range of NGS-based tests to clinicians around the UK. These services were the beginnings of our laboratory today.

In August 2016, HCA UK took full ownership of UCLAD’s molecular pathology laboratory, in order to improve the commercialisation of exitsing tests in addition to developing new ones. They renamed the laboratory Sarah Cannon Molecular Diagnostics, or SCMD, to recognise the support that Sarah Cannon would offer. This combined expertise from UCL, HCA UK and Sarah Cannon is what makes our laboratory so special today.

Our technology

Right now, we focus on Next Generation Sequencing, or NGS, for cancer patients with solid tumours. This technology allows us to analyse a large number of genes within a tumour simultaneously, gathering information about what is driving the cancer and whether certain treatments, therapies, or trials might help to fight it. When new, successful technologies emerge we’ll explore those too, to improve outcomes both for patients and for the wider industry.

DNA Sequencing Chip

Our Team

SCMD Staff

Lead Scientists

Dr Phil Bennett

Principal Clinical Scientist

Phil is the service lead for SCMD and has been a registered clinical scientist for over ten years, applying the latest developments in molecular diagnostics across a range of service areas including microbiology, virology, clinical & forensic genetics and most recently molecular pathology.

Phil has overseen the launch and growth of the Next Generation Sequencing based tumour profiling service and the transfer of the business from UCL to HCA. With an increase in investment and resources arising from this transfer, Phil is now tasked with further expanding the business, both with regards to consolidation of existing service lines and the development of new ones.

Once a keen skier, canoeist and mountain biking, many of his hobbies have been on the back burner since children arrived on the scene, but he still manages to find time to fit in some scuba diving both in the UK and farther afield.

Dr Gareth Gerrard

Research and Development Lead

Gareth is an honorary lecturer at Imperial College and co-organises the Pharmacogenomics and Translational Medicine module of the MSc Genomic Medicine. He also teaches on the UCL MSc Cancer course.

Having gained undergraduate and master’s degrees at the University of Wales in Cardiff, and a PhD at the Royal Free and UCL Medical School, he began his postdoctoral career in molecular pathology at UCL. He also worked at Imperial College, monitoring residual disease in patients with leukaemia, before heading back to UCL to manage the Cancer Institute Pathology Core Facility. He joined us in 2017 to help drive molecular and genomic assay development.

Outside clinical genomics, he’s true to his Welsh genetic predisposition by being an avid follower of The Rugby.

Ben Poskitt

Lead Bio-Medical Scientist

After graduating from the University of Hull, Ben joined Sheffield Teaching Hospitals as a trainee Biomedical Scientist. There he found his interests lay in solid tissue laboratory sciences. Qualifying in 2007, he moved to Imperial College Healthcare NHS Trust and gained experience of clinical immunohistochemistry. He subsequently did a part-time MSc in Cellular Pathology, with a project centred on acquired mutations in cancer.

Since joining our team, Ben has been the interface between solid tissue pathology and molecular genetics, relying on his laboratory experience in both disciplines. He’s now continuing and expanding this role.

Ben is a motorcyclist, guitarist, and keen chef. A home brewer of craft beers, he can often be found conducting thorough research for his next recipe.

Dr Kevin Balbi

Bioinformatician

Kevin has a degree in Molecular and Cellular Biology and a PhD in Evolutionary Genetics. He held a research position at Imperial College, examining genetic diversity in soil bacteria, and has worked in a large data centre supporting server configuration and deployment.

He writes and maintains the informatics pipelines and IT systems that handle the vast amounts of data involved in genetic analysis. He has expanded existing pipelines to bring additional information into our reports, and has overseen construction of a new information management system.

Outside work, Kevin enjoys gaming, reading, and rambling. He volunteers running a Code Club at his local library, helping children learn to write computer programs.

Philip.Bennett@HCAHealthcare.co.uk

Tel: +44(0)20 3794 1920

Gareth.Gerrard@HCAHealthcare.co.uk

Tel: +44(0)20 3794 1928

Benjamin.Poskitt@HCAHealthcare.co.uk

Tel: +44(0)20 3794 1929

Kevin.Balbi@HCAHealthcare.co.uk

Tel: +44(0)20 3794 1924

Genomics Review Board

This is a team of world-renowned clinicians and scientists who support HCA clinicians and other customers by reviewing what can be quite complex outcomes from a range of genetic and other analyses, before recommending the best way forward.

Our board members understand which clinical trials are in progress, and which new technologies are becoming available – so their recommendations are always up to date with the latest thinking. Very few people in the UK can do what they do.

The Board is lead by Dr Tobi Arkenau and includes Prof. Charles Swanton and Dr Martin Forster amongst others.

Clinical Strategy Board

Our Clinical Strategy Board sets the overarching clinical strategy across all HCA Laboratories. Members meet regularly to review what’s happening in the wider industry, and to agree which tests our own laboratories should develop and offer in response. The members are: